When Is It Too Late to Get RhoGAM Shot?

It is better to get a RhoGAM shot within the first trimester of pregnancy for the Rh-negative women.

Even if you have any experienced pregnancy loss or miscarriage, you should get it before 2nd time of pregnancy. 

So it may be a simple, safe, and efficient way to prevent any possible problems — both present and for further pregnancies. 

When your Rh-negative blood mixes with your baby’s Rh-positive blood during the first pregnancy, it may not cause any difficulty according to the FDA safety recommendation.

Because blood mixing usually happens during childbirth, it takes just about one month before your body can make exact antibodies for Rh-positive blood. 

But the subsequent pregnancy, if you have another Rh-positive baby, may cause Rh diseases.

Moreover, your baby may develop severe fetal anemia or other fatal diseases while in the womb. For example, hydrops fetal and erythroblastosis fetalis.  

They are also some risk of intense situations like as:

  • Seizures or uncontrolled tremors, jerking or twitching movements
  • deficient levels or Hypoglycemia of blood sugar (glucose)
  • Brain damage
  • Heart failure

When is it too late to get rhogam shot

Many doctors recommend RhoGAM shots around 26 to 28 weeks of pregnancy. Somehow if you don’t get the injection within this time, it may be late. Or it may be too late once your blood mixes with your baby’s blood.

when is it too late to get rhogam shot
when is it too late to get rhogam shot

When is it too late to get RhoGAM shot after miscarriage?

Usually, it recommends getting RhoGAM shot after the start of the miscarriage within 72 hours.

Although it is too late to get a RhoGAM injection, more than 72 hours after your miscarriage, don’t worry or panic. The shot is not likely to create a difference.

However, the odds of becoming sensitized against the Rhesus(Rh) factor are low. Even then, you should better get a RhoGAM shot as it has a risk though lower.

Is getting RhoGAM shot too late after 28 weeks pregnancy?

Most healthcare providers recommend getting RhoGAM shot around 28 weeks of pregnancy. But you may accept it later.

According to some reports of pregnant women, they take RhoGAM shots after 30 to 32 weeks of gestation and give birth to a healthy baby.

Anyway, it is better to get the RhoGAM shot early if the doctor advised to get it. Whether, unfortunately, you and your baby’s blood have mixed, there will be no way to survive anymore without RhoGAM shot. So you should better get it earlier.

Is RhoGAM shot late after 30 weeks?

It’s never too late to get a RhoGAM shot at 30 weeks. These shots may be given as late as 38 weeks of gestation and protect infants from the potential complications of Rh incompatibility. Until, you get to see the baby is active at 35 weeks of pregnancy, you can easily take that shot.

If the mom and babies’ blood are sensitized, it means too late to get a RhoGAM shot.

What happens if you get RhoGAM shot late after abortion?

After an abortion, you should get a RhoGAM shot as early as possible or within three days. Otherwise, it is a chance to have Rh incompatibility in your baby during your 2nd-time gestation. 

There also will be a chance to sensitize the blood of both mom and baby. So you may need to take the 2nd dose of the RhoGAM. 

But, you will not need the second dose if your baby’s blood is Rh-negative.

When to take a RhoGAM shot?

If your doctor ensures the presence of Rh incompatibility or other Rh diseases in your body, you should take a RhoGAM injection. It helps prevent certain types of birth deficiencies. It gives as an injection.

However, taking a RhoGAM shot is the only protective measure to prevent future complications owing to Rh incompatibility. For this reason, time management is the key.

Indication and usage of RhoGam shot during pregnancy

  • Around 26 to 28 weeks of your pregnancy, when the placenta can begin to thin and unlikely, blood can move from baby to mother
  • Within 72 hours of your delivery, if the baby is Rh-positive, including a cesarean release.
  • Early pregnancy spotting and vaginal bleeding during pregnancy
  • After the trauma to the abdomen or midsection, that may happen after a car accident or fall.
  • Any operation on the fetus — for instance, when a doctor turns an unborn child settled in the breech position.
  • After a stillbirth, abortion, pregnancy loss or miscarriage, or an ectopic pregnancy 
  • After any invasive testing of the baby’s cells, for example, during amniocentesis or CVS (chorionic villus sampling)

Anyway, for every subsequent pregnancy after the first, RhoGAM will be needed to administer at usual intervals, especially through the second half of the pregnancy.

Anyway, if you suffer any unusual things after getting the RhoGAM shot, as early as possible, contact your healthcare provider.

When not to get a RhoGAM shot?

Skip the skepticism as RhoGAM shots are commonly safe! Yet, in some cases, it may be unsafe for you especially when you are RH positive.

According to Dailymed (FDA certified) when you should not get a RhoGAM shot. Such as:

Pregnancy and other obstetrical conditions
RhoGAM and MICRhoGAM are indicated for administration to Rh-negative women not previously sensitized to the Rho(D) factor, unless the father or baby are conclusively Rh-negative, in case of:

Delivery of an Rh-positive baby irrespective of the ABO groups of the mother and baby
Antepartum prophylaxis at 26 to 28 weeks gestation.

Antepartum fetal-maternal hemorrhage (suspected or proven) as a result of placenta previa, amniocentesis, chorionic villus sampling, percutaneous umbilical blood sampling, other obstetrical manipulative procedure (e.g., version) or abdominal trauma

Actual or threatened pregnancy loss at any stage of gestation

Ectopic pregnancy



  1. In the case of postpartum use, RhoGAM and MICRhoGAM are intended for maternal administration. Do not inject the newborn infant
  2. Severe hypersensitivity reactions may occur with the use of RhoGAM/MICRhoGAM, even in patients who have tolerated previous administrations.
  3. Anaphylactic or severe systemic reactions
  4. Because RhoGAM and MICRhoGAM are made from human blood, they may carry a risk of transmitting infectious agents
  5. Do not apply, if you are RH positive since you may face some disorders like: hemolytic reaction, including fever, back pain, nausea and vomiting, hypo- or hypertension, hemoglobinuria/emia, elevated bilirubin and creatinine and decreased haptoglobin
Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d87e4d0b-2442-4135-b3f9-5c4f74845b87#section-1.2

So if your doctor suggests getting RhoGAM, there is no way to skip it. Make sure you run a test for it.

Sarah, a health writer and editor since 2014, is an adoring wife and dedicated mother to 2 daughters and 1 son. As the creator of Babies Plannet, she combines her extensive expertise with her maternal dedication to provide essential care and safety advice for infants, nurturing their well-being and happiness. Her writing explores topics like fitness, pregnancy, and women's healthy lifestyles.

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I am a woman with rh inconpactibility but had already had a child without the rhROGAM shot. Does it mean i cannot have a child again?

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